Accelerated fast spin echo diffusion spectrum imaging in the mouse heart ex-vivo
نویسندگان
چکیده
Background Probing the microscale diffusion of water informs on cardiac microstructural features such as cell density and orientation. Diffusion spectrum imaging (DSI) is widely regarded as the gold standard as it measures diffusion in a model-free manner. However, acquisition times are prolonged due to high sampling requirements in qspace. Various methods of reducing acquisition times have been explored, including the use of echo planar imaging [1], and compressed sensing [2,3]. Here we investigate acquiring DSI data using an 8-fold accelerated diffusion-weighted fast spin echo (DW-FSE) pulse sequences versus a diffusion-weighted spin echo (DWSE) reference.
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Ex vivo cardiac DTI: on the effects of diffusion time and b-value
Background For in-vivo an ex-vivo studies of myocardial structure, generally a spin echo (SE) or stimulated echo (STE) based sequence is used. Diffusion weighting is reported with a large range of diffusion times (50 and 1000 ms). Furthermore, in-vivo studies generally use low b-values (300 s/mm) whereas ex-vivo experiments allow for much higher b-values. For interpretation of in-vivo cardiac D...
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